Satoshi, Kasumi, and Takeshi continue exploring the Johto region, then have to rescue Pikachu after Musashi and Kojiro kidnap him. The search leads them to the hidden plateau where Mewtwo has established a haven for the cloned Pokémon from the previous film. The evil Sakaki is plotting to recapture Mewtwo and renew his efforts to create an army of bio-engineered Pokémon. Aided by the reluctant Nyarth, Ash and his friends defeat Sakaki and his henchman.
- Genre: Animation, Family, Action, Adventure, Drama, Fantasy
- Studio: Anime World Osaka, JR Kikaku, OLM, Shogakukan Production, Snow Light Staff, Studio Jack, TV Tokyo
- Keyword: based on video game, anime, based on tv series, original video animation
- Cast: Rica Matsumoto, Ikue Otani, Mayumi Iizuka, Satomi Korogi, Yuji Ueda, Megumi Hayashibara